A New Generation of Serotype Chimeric Infectivity-Enhanced Conditionally Replicative Adenovirals: The Safety Profile of Ad5/3-Δ24 in Advance of a Phase I Clinical Trial in Ovarian Cancer Patients

Conditionally replicative adenoviral (CRAd) virotherapy represents a promising therapeutic approach for cancer. We have demonstrated that a serotype chimeric adenoviral 5/3 fiber-knob modification achieves enhanced ovarian cancer infectivity, conditional replication, and oncolytic activity. This stu...

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Hlavní autoři: Kim, Kenneth H., Ryan, Michael J., Estep, James E., Miniard, Brock M., Rudge, Thomas L., Peggins, James O., Broadt, Trevor L., Wang, Minghui, Preuss, Meredith A., Siegal, Gene P., Hemminki, Akseli, Harris, Raymond D., Aurigemma, Rosemarie, Curiel, David T., Alvarez, Ronald D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2011
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135257/
https://ncbi.nlm.nih.gov/pubmed/21171861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2010.180
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