Molecular modeling and in vivo imaging can identify successful flexible triazine dendrimer-based siRNA delivery systems

This study aimed to identify suitable siRNA delivery systems based on flexible generation 2–4 triazine dendrimers by correlating physico-chemical and biological in vitro and in vivo properties of the complexes with thermodynamic parameters calculated using molecular modeling. The siRNA binding prope...

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Autori principali: Merkel, Olivia M., Zheng, Mengyao, Mintzer, Meredith A., Pavan, Giovanni M., Librizzi, Damiano, Maly, Marek, Höffken, Helmut, Danani, Andrea, Simanek, Eric E., Kissel, Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3134114/
https://ncbi.nlm.nih.gov/pubmed/21342661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2011.02.016
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