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A Runx1-Smad6 Rheostat Controls Runx1 Activity during Embryonic Hematopoiesis

The oncogenic transcription factor Runx1 is required for the specification of definitive hematopoietic stem cells (HSC) in the developing embryo. The activity of this master regulator is tightly controlled during development. The transcription factors that upregulate the expression of Runx1 also upr...

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Hlavní autoři: Knezevic, Kathy, Bee, Thomas, Wilson, Nicola K., Janes, Mary E., Kinston, Sarah, Polderdijk, Stéphanie, Kolb-Kokocinski, Anja, Ottersbach, Katrin, Pencovich, Niv, Groner, Yoram, de Bruijn, Marella, Göttgens, Berthold, Pimanda, John E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133398/
https://ncbi.nlm.nih.gov/pubmed/21576367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01305-10
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