A Runx1-Smad6 Rheostat Controls Runx1 Activity during Embryonic Hematopoiesis

The oncogenic transcription factor Runx1 is required for the specification of definitive hematopoietic stem cells (HSC) in the developing embryo. The activity of this master regulator is tightly controlled during development. The transcription factors that upregulate the expression of Runx1 also upr...

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Autors principals: Knezevic, Kathy, Bee, Thomas, Wilson, Nicola K., Janes, Mary E., Kinston, Sarah, Polderdijk, Stéphanie, Kolb-Kokocinski, Anja, Ottersbach, Katrin, Pencovich, Niv, Groner, Yoram, de Bruijn, Marella, Göttgens, Berthold, Pimanda, John E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2011
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133398/
https://ncbi.nlm.nih.gov/pubmed/21576367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01305-10
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