Cysteine 27 Variant of the δ-Opioid Receptor Affects Amyloid Precursor Protein Processing through Altered Endocytic Trafficking

Agonist-induced activation of the δ-opioid receptor (δOR) was recently shown to augment β- and γ-secretase activities, which increased the production of β-amyloid peptide (Aβ), known to accumulate in the brain tissues of Alzheimer's disease (AD) patients. Previously, the δOR variant with a phen...

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Hauptverfasser: Sarajärvi, Timo, Tuusa, Jussi T., Haapasalo, Annakaisa, Lackman, Jarkko J., Sormunen, Raija, Helisalmi, Seppo, Roehr, Johannes T., Parrado, Antonio R., Mäkinen, Petra, Bertram, Lars, Soininen, Hilkka, Tanzi, Rudolph E., Petäjä-Repo, Ulla E., Hiltunen, Mikko
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2011
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133236/
https://ncbi.nlm.nih.gov/pubmed/21464208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05015-11
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