Down-regulation of Seladin-1 Increases BACE1 Levels and Activity through Enhanced GGA3 Depletion during Apoptosis

Seladin-1 is a neuroprotective protein selectively down-regulated in brain regions affected in Alzheimer disease (AD). Seladin-1 protects cells against β-amyloid (Aβ) peptide 42- and oxidative stress-induced apoptosis activated by caspase-3, a key mediator of apoptosis. Here, we have employed RNA in...

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Bibliographische Detailangaben
Hauptverfasser: Sarajärvi, Timo, Haapasalo, Annakaisa, Viswanathan, Jayashree, Mäkinen, Petra, Laitinen, Marjo, Soininen, Hilkka, Hiltunen, Mikko
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797211/
https://ncbi.nlm.nih.gov/pubmed/19815556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.036202
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