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Blocking the Apolipoprotein E/Amyloid-β Interaction Reduces Fibrillar Vascular Amyloid Deposition and Cerebral Microhemorrhages in TgSwDI Mice

The accumulation of amyloid-β (Aβ) peptides as toxic oligomers, amyloid plaques, and cerebral amyloid angiopathy (CAA) is critical in the pathogenesis of Alzheimer’s disease (AD). The binding of Aβ peptides to apolipoprotein E (ApoE) plays an important role in modulation of amyloid deposition and cl...

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Autors principals: Yang, Jing, Ji, Yong, Mehta, Pankaj, Bates, Kristyn A., Sun, Yanjie, Wisniewski, Thomas
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3132897/
https://ncbi.nlm.nih.gov/pubmed/21239853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2011-101401
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