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Regulation of EGFR Protein Stability by the HECT-type Ubiquitin Ligase SMURF2

Epidermal growth factor receptor (EGFR) is overexpressed in a variety of epithelial tumors and is considered to be an important therapeutic target. Although gene amplification is responsible for EGFR overexpression in certain human malignancies including lung and head and neck cancers, additional mo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ray, Dipankar, Ahsan, Aarif, Helman, Abigail, Chen, Guoan, Hegde, Ashok, Gurjar, Susmita Ramanand, Zhao, Lili, Kiyokawa, Hiroaki, Beer, David G, Lawrence, Theodore S, Nyati, Mukesh K
Format: Artigo
Sprache:Inglês
Veröffentlicht: Neoplasia Press Inc. 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3132843/
https://ncbi.nlm.nih.gov/pubmed/21750651
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