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CCN2 Is Required for the TGF-β Induced Activation of Smad1 - Erk1/2 Signaling Network

Connective tissue growth factor (CCN2) is a multifunctional matricellular protein, which is frequently overexpressed during organ fibrosis. CCN2 is a mediator of the pro-fibrotic effects of TGF-β in cultured cells, but the specific function of CCN2 in the fibrotic process has not been elucidated. In...

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Detalhes bibliográficos
Main Authors: Nakerakanti, Sashidhar S., Bujor, Andreea M., Trojanowska, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3132735/
https://ncbi.nlm.nih.gov/pubmed/21760921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021911
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