Autocrine transforming growth factor β signaling regulates extracellular signal-regulated kinase 1/2 phosphorylation via modulation of protein phosphatase 2A expression in scleroderma fibroblasts

BACKGROUND: During scleroderma (SSc) pathogenesis, fibroblasts acquire an activated phenotype characterized by enhanced production of extracellular matrix (ECM) and constitutive activation of several major signaling pathways including extracellular signal-related kinase (ERK1/2). Several studies hav...

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Main Authors: Samuel, Glady H, Bujor, Andreea M, Nakerakanti, Sashidhar S, Hant, Faye N, Trojanowska, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3008687/
https://ncbi.nlm.nih.gov/pubmed/21134273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-1536-3-25
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