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Akt inhibition up-regulates MMP1 through a CCN2-dependent pathway in human dermal fibroblasts
Akt is a key signalling molecule that was found to be down-regulated in chronic wounds. Akt blockade has dual antifibrotic effects in human dermal fibroblasts, by up-regulating matrix metalloproteinase 1 (MMP1) and down-regulating collagen gene expression (J Invest Dermatol 2008: 128: 1906). The aim...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3826663/ https://ncbi.nlm.nih.gov/pubmed/20201953 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0625.2010.01065.x |
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