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Akt inhibition up-regulates MMP1 through a CCN2-dependent pathway in human dermal fibroblasts

Akt is a key signalling molecule that was found to be down-regulated in chronic wounds. Akt blockade has dual antifibrotic effects in human dermal fibroblasts, by up-regulating matrix metalloproteinase 1 (MMP1) and down-regulating collagen gene expression (J Invest Dermatol 2008: 128: 1906). The aim...

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Autori principali: Bujor, Andreea M., Nakerakanti, Sashidar, Morris, Erin, Hant, Faye N., Trojanowska, Maria
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3826663/
https://ncbi.nlm.nih.gov/pubmed/20201953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0625.2010.01065.x
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