Endoglin promotes TGF-β/Smad1 signaling in scleroderma fibroblasts

TGF-β is the primary inducer of extracellular matrix (ECM) proteins in scleroderma (systemic sclerosis, SSc). Previous studies indicate that in a subset of SSc fibroblasts TGF-β signaling is activated via elevated levels of activin receptor-like kinase (ALK) 1 and phosphorylated Smad1 (pSmad1). The...

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Autori principali: Morris, Erin, Chrobak, Izabela, Bujor, Andreea, Hant, Faye, Mummery, Christine, Dijke, Peter ten, Trojanowska, Maria
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381731/
https://ncbi.nlm.nih.gov/pubmed/21344387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.22690
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