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Endoglin promotes TGF-β/Smad1 signaling in scleroderma fibroblasts
TGF-β is the primary inducer of extracellular matrix (ECM) proteins in scleroderma (systemic sclerosis, SSc). Previous studies indicate that in a subset of SSc fibroblasts TGF-β signaling is activated via elevated levels of activin receptor-like kinase (ALK) 1 and phosphorylated Smad1 (pSmad1). The...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3381731/ https://ncbi.nlm.nih.gov/pubmed/21344387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.22690 |
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