11β-Hydroxysteroid Dehydrogenase Type 1 Deficiency Prevents Memory Deficits with Aging by Switching from Glucocorticoid Receptor to Mineralocorticoid Receptor-Mediated Cognitive Control

Local brain amplification of glucocorticoids (GCs) by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) plays a pivotal role in age-related memory deficits. 11β-HSD1 deficient mice are protected from spatial memory impairments with aging, but the underlying mechanisms are unknown. To determine whic...

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Hlavní autoři: Yau, Joyce L. W., Noble, June, Seckl, Jonathan R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2011
Témata:
Brief Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3132450/
https://ncbi.nlm.nih.gov/pubmed/21411659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6145-10.2011
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