11β-Hydroxysteroid Dehydrogenase Type 1 Expression Is Increased in the Aged Mouse Hippocampus and Parietal Cortex and Causes Memory Impairments

Increased neuronal glucocorticoid exposure may underlie interindividual variation in cognitive function with aging in rodents and humans. 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyzes the regeneration of active glucocorticoids within cells (in brain and other tissues), thus amplifying...

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Detaylı Bibliyografya
Asıl Yazarlar: Holmes, Megan C., Carter, Roderick N., Noble, June, Chitnis, Shruti, Dutia, Amy, Paterson, Janice M., Mullins, John J., Seckl, Jonathan R., Yau, Joyce L. W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Society for Neuroscience 2010
Konular:
Brief Communications
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885438/
https://ncbi.nlm.nih.gov/pubmed/20484633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0731-10.2010
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