Liver-Selective Transgene Rescue of Hypothalamic-Pituitary-Adrenal Axis Dysfunction in 11βHydroxysteroid Dehydrogenase Type 1-Deficient Mice

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) acts as a reductase in vivo, regenerating active glucocorticoids within cells from circulating inert 11-keto forms, thus amplifying local glucocorticoid action. 11β-HSD1 is predominantly expressed in liver and also adipose tissue and brain. Mice def...

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Détails bibliographiques
Publié dans:Endocrinology
Auteurs principaux: Paterson, Janice M., Holmes, Megan C., Kenyon, Christopher J., Carter, Roderick, Mullins, John J., Seckl, Jonathan R.
Format: Artigo
Langue:Inglês
Publié: 2006
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6443039/
https://ncbi.nlm.nih.gov/pubmed/17170103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2006-0603
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