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Liver-Selective Transgene Rescue of Hypothalamic-Pituitary-Adrenal Axis Dysfunction in 11βHydroxysteroid Dehydrogenase Type 1-Deficient Mice
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) acts as a reductase in vivo, regenerating active glucocorticoids within cells from circulating inert 11-keto forms, thus amplifying local glucocorticoid action. 11β-HSD1 is predominantly expressed in liver and also adipose tissue and brain. Mice def...
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| Publicado en: | Endocrinology |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2006
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6443039/ https://ncbi.nlm.nih.gov/pubmed/17170103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2006-0603 |
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