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Liver-Selective Transgene Rescue of Hypothalamic-Pituitary-Adrenal Axis Dysfunction in 11βHydroxysteroid Dehydrogenase Type 1-Deficient Mice
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) acts as a reductase in vivo, regenerating active glucocorticoids within cells from circulating inert 11-keto forms, thus amplifying local glucocorticoid action. 11β-HSD1 is predominantly expressed in liver and also adipose tissue and brain. Mice def...
में बचाया:
| में प्रकाशित: | Endocrinology |
|---|---|
| मुख्य लेखकों: | , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2006
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6443039/ https://ncbi.nlm.nih.gov/pubmed/17170103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2006-0603 |
| टैग : |
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