Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acid-aminopterin conjugate

INTRODUCTION: Folate receptor (FR)-expressing macrophages have been shown to accumulate at sites of inflammation, where they promote development of inflammatory symptoms. To target such a macrophage population, we designed and evaluated the biologic activity of EC0746, a novel folic acid conjugate o...

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Autors principals: Lu, Yingjuan, Stinnette, Torian W, Westrick, Elaine, Klein, Patrick J, Gehrke, Mark A, Cross, Vicky A, Vlahov, Iontcho R, Low, Philip S, Leamon, Christopher P
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3132048/
https://ncbi.nlm.nih.gov/pubmed/21463515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3304
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