Efficacy and tolerability of folate-aminopterin therapy in a rat focal model of multiple sclerosis

BACKGROUND: Activated macrophages in the experimental model of multiple sclerosis (MS) express folate receptor-β (FR-β), representing a promising target for the treatment of MS. Here, we both evaluated the efficacy of a novel folate-aminopterin construct (EC2319) in a rat focal model of multiple scl...

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Pubblicato in:J Neuroinflammation
Autori principali: Elo, Petri, Li, Xiang-Guo, Liljenbäck, Heidi, Gardberg, Maria, Moisio, Olli, Miner, Maxwell, Virta, Jenni, Saraste, Antti, Srinivasarao, Madduri, Pugh, Michael, Low, Philip S., Knuuti, Juhani, Jalkanen, Sirpa, Airas, Laura, Lu, Yingjuan June, Roivainen, Anne
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2021
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7819223/
https://ncbi.nlm.nih.gov/pubmed/33472663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-021-02073-7
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