Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington's disease

Huntington's disease (HD) is a fatal neurodegenerative disorder caused by expansion of a polyglutamine tract in the huntingtin protein (htt) that mediates formation of intracellular protein aggregates. In the brains of HD patients and HD transgenic mice, accumulation of protein aggregates has b...

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Main Authors: Richards, P, Didszun, C, Campesan, S, Simpson, A, Horley, B, Young, K W, Glynn, P, Cain, K, Kyriacou, C P, Giorgini, F, Nicotera, P
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131896/
https://ncbi.nlm.nih.gov/pubmed/21217767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.127
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