Evolution of cyclic peptide protease inhibitors

We report a bacterial system for the evolution of cyclic peptides that makes use of an expanded set of amino acid building blocks. Orthogonal aminoacyl-tRNA synthetase/tRNA(CUA) pairs, together with a split intein system were used to biosynthesize a library of ribosomal peptides containing amino aci...

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Bibliographic Details
Main Authors: Young, Travis S., Young, Douglas D., Ahmad, Insha, Louis, John M., Benkovic, Stephen J., Schultz, Peter G.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131355/
https://ncbi.nlm.nih.gov/pubmed/21690365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1108045108
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