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Evolution of cyclic peptide protease inhibitors
We report a bacterial system for the evolution of cyclic peptides that makes use of an expanded set of amino acid building blocks. Orthogonal aminoacyl-tRNA synthetase/tRNA(CUA) pairs, together with a split intein system were used to biosynthesize a library of ribosomal peptides containing amino aci...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3131355/ https://ncbi.nlm.nih.gov/pubmed/21690365 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1108045108 |
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