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Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease

A method to rapidly screen libraries of cyclic peptides in vivo for molecules with biological activity has been developed and used to isolate cyclic peptide inhibitors of the ClpXP protease. Fluorescence activated cell sorting was used in conjunction with a fluorescent reporter to isolate cyclic pep...

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Autors principals: Cheng, Lin, Naumann, Todd A., Horswill, Alexander R., Hong, Sue-Jean, Venters, Bryan J., Tomsho, John W., Benkovic, Stephen J., Keiler, Kenneth C.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2203360/
https://ncbi.nlm.nih.gov/pubmed/17600141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.072933007
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