Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease

A method to rapidly screen libraries of cyclic peptides in vivo for molecules with biological activity has been developed and used to isolate cyclic peptide inhibitors of the ClpXP protease. Fluorescence activated cell sorting was used in conjunction with a fluorescent reporter to isolate cyclic pep...

Full description

Saved in:
Bibliographic Details
Main Authors: Cheng, Lin, Naumann, Todd A., Horswill, Alexander R., Hong, Sue-Jean, Venters, Bryan J., Tomsho, John W., Benkovic, Stephen J., Keiler, Kenneth C.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2007
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2203360/
https://ncbi.nlm.nih.gov/pubmed/17600141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.072933007
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items