A cyclic peptide inhibitor of the SARS-CoV-2 main protease

This paper presents the design and study of a first-in-class cyclic peptide inhibitor against the SARS-CoV-2 main protease (M(pro)). The cyclic peptide inhibitor is designed to mimic the conformation of a substrate at a C-terminal autolytic cleavage site of M(pro). The cyclic peptide contains a [4-(...

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Publicado en:Eur J Med Chem
Autores principales: Kreutzer, Adam G., Krumberger, Maj, Diessner, Elizabeth M., Parrocha, Chelsea Marie T., Morris, Michael A., Guaglianone, Gretchen, Butts, Carter T., Nowick, James S.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Author(s). Published by Elsevier Masson SAS. 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8096527/
https://ncbi.nlm.nih.gov/pubmed/34023738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2021.113530
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