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Sequence characterization and molecular modeling of clinically relevant variants of the SARS-CoV-2 main protease
The SARS-CoV-2 main protease (M(pro)) is essential to viral replication and cleaves highly specific substrate sequences, making it an obvious target for inhibitor design. However, as for any virus, SARS-CoV-2 is subject to constant neutral drift and selection pressure, with new M(pro) mutations aris...
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| 出版年: | Biochemistry |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7518256/ https://ncbi.nlm.nih.gov/pubmed/32931703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00462 |
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