Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor–coactivator interactions

The interaction between nuclear receptors and coactivators provides an arena for testing whether protein–protein interactions may be inhibited by small molecule drug candidates. We provide evidence that a short cyclic peptide, containing a copy of the LXXLL nuclear receptor box pentapeptide, binds t...

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Detalhes bibliográficos
Main Authors: Leduc, Anne-Marie, Trent, John O., Wittliff, James L., Bramlett, Kelli S., Briggs, Stephen L., Chirgadze, Nikolay Y., Wang, Yong, Burris, Thomas P., Spatola, Arno F.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC208747/
https://ncbi.nlm.nih.gov/pubmed/13679575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1934759100
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