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Translesion Synthesis Across 1,N(2)-Ethenoguanine by Human DNA Polymerases
1,N(2)-Etheno(ε)guanine (ε) is formed in DNA as a result of exposure to certain vinyl monomers (e.g. vinyl chloride) or from lipid peroxidation. This lesion has been shown to be mutagenic in bacteria and mammalian cells. 1,N(2)-ε-G has been shown to block several model replicative DNA polymerases, w...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3130186/ https://ncbi.nlm.nih.gov/pubmed/16780368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx060051v |
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