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Hypothalamic Leptin Gene Therapy Prevents Weight Gain without Long-term Detrimental Effects on Bone in Growing and Skeletally Mature Female Rats

Hypothalamic leptin gene therapy normalizes the mosaic skeletal phenotype of leptin-deficient ob/ob mice. However, it is not clear whether increased hypothalamic leptin alters bone metabolism in animals already producing the hormone. The objective of this study was to evaluate the long duration effe...

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Bibliografiske detaljer
Main Authors: Iwaniec, U.T., Boghossian, S., Trevisiol, C.H., Wronski, T.J., Turner, R.T., Kalra, S.P.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129999/
https://ncbi.nlm.nih.gov/pubmed/21328617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.365
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