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Hypothalamic Leptin Gene Therapy Prevents Weight Gain without Long-term Detrimental Effects on Bone in Growing and Skeletally Mature Female Rats
Hypothalamic leptin gene therapy normalizes the mosaic skeletal phenotype of leptin-deficient ob/ob mice. However, it is not clear whether increased hypothalamic leptin alters bone metabolism in animals already producing the hormone. The objective of this study was to evaluate the long duration effe...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3129999/ https://ncbi.nlm.nih.gov/pubmed/21328617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.365 |
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