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Hypothalamic Leptin Gene Therapy Prevents Weight Gain without Long-term Detrimental Effects on Bone in Growing and Skeletally Mature Female Rats
Hypothalamic leptin gene therapy normalizes the mosaic skeletal phenotype of leptin-deficient ob/ob mice. However, it is not clear whether increased hypothalamic leptin alters bone metabolism in animals already producing the hormone. The objective of this study was to evaluate the long duration effe...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3129999/ https://ncbi.nlm.nih.gov/pubmed/21328617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.365 |
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