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MicroRNA Regulation of Glycoprotein B5R in Oncolytic Vaccinia Virus Reduces Viral Pathogenicity Without Impairing Its Antitumor Efficacy

Vaccinia virus, once widely used for smallpox vaccine, has recently been engineered and used as an oncolytic virus for cancer virotherapy. Their replication has been restricted to tumors by disrupting viral genes and complementing them with products that are found specifically in tumor cells. Here,...

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Detalhes bibliográficos
Main Authors: Hikichi, Mina, Kidokoro, Minoru, Haraguchi, Takeshi, Iba, Hideo, Shida, Hisatoshi, Tahara, Hideaki, Nakamura, Takafumi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129806/
https://ncbi.nlm.nih.gov/pubmed/21386827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.36
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