Enhancers of Adeno-associated Virus AAV2 Transduction via High Throughput siRNA Screening

Intracellular barriers to adeno-associated virus (AAV) transduction may limit gene delivery. We screened a short interfering RNA (siRNA) library targeting 5,520 genes to help identify pathways that modulate AAV transduction of human endothelium. In replicate screening, 50 pools (three siRNAs per gen...

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Detalhes bibliográficos
Main Authors: Wallen, Alexis J, Barker, Gregory A, Fein, David E, Jing, Huiyan, Diamond, Scott L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129788/
https://ncbi.nlm.nih.gov/pubmed/21304495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.4
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