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Diacylglycerol kinase zeta deficiency in a non-CD4(+)T cell compartment leads to increased peanut hypersensitivity

Peanut sensitization in diacylglycerol kinase zeta (DGKζ) deficient mice led to elevated peanut-IgE levels and severe anaphylaxis. DGKζ deficient CD4(+)T cells did not account for the phenotype. Future studies will determine which immune lineage caused increased food hypersensitivity.

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Bibliografische gegevens
Hoofdauteurs: Kulis, Mike, Wan, Chi-Keung, Gorentla, Balachandra K., Burks, A. Wesley, Zhong, Xiao-Ping
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129393/
https://ncbi.nlm.nih.gov/pubmed/21439625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2011.02.035
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