An “Exacerbate-reverse” Strategy in Yeast Identifies Histone Deacetylase Inhibition as a Correction for Cholesterol and Sphingolipid Transport Defects in Human Niemann-Pick Type C Disease

Niemann-Pick type C (NP-C) disease is a fatal lysosomal lipid storage disorder for which no effective therapy exists. A genome-wide, conditional synthetic lethality screen was performed using the yeast model of NP-C disease during anaerobiosis, an auxotrophic condition that requires yeast to utilize...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Munkacsi, Andrew B., Chen, Fannie W., Brinkman, Matthew A., Higaki, Katsumi, Gutiérrez, Giselle Domínguez, Chaudhari, Jagruti, Layer, Jacob V., Tong, Amy, Bard, Martin, Boone, Charles, Ioannou, Yiannis A., Sturley, Stephen L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2011
Gaiak:
Molecular Bases of Disease
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129166/
https://ncbi.nlm.nih.gov/pubmed/21489983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.227645
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