An “Exacerbate-reverse” Strategy in Yeast Identifies Histone Deacetylase Inhibition as a Correction for Cholesterol and Sphingolipid Transport Defects in Human Niemann-Pick Type C Disease

Niemann-Pick type C (NP-C) disease is a fatal lysosomal lipid storage disorder for which no effective therapy exists. A genome-wide, conditional synthetic lethality screen was performed using the yeast model of NP-C disease during anaerobiosis, an auxotrophic condition that requires yeast to utilize...

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Bibliografische gegevens
Hoofdauteurs: Munkacsi, Andrew B., Chen, Fannie W., Brinkman, Matthew A., Higaki, Katsumi, Gutiérrez, Giselle Domínguez, Chaudhari, Jagruti, Layer, Jacob V., Tong, Amy, Bard, Martin, Boone, Charles, Ioannou, Yiannis A., Sturley, Stephen L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2011
Onderwerpen:
Molecular Bases of Disease
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129166/
https://ncbi.nlm.nih.gov/pubmed/21489983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.227645
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