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Homologous Recombination Conserves DNA Sequence Integrity Throughout the Cell Cycle in Embryonic Stem Cells

The maintenance of genomic integrity is crucial to embryonic stem cells (ESC) considering the potential for propagating undesirable mutations to the resulting somatic and germ cell lineages. Indeed, mouse ESC (mESC) exhibit a significantly lower mutation frequency compared to differentiated cells. T...

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Bibliografski detalji
Glavni autori: Serrano, Lourdes, Liang, Li, Chang, Yiming, Deng, Li, Maulion, Christopher, Nguyen, Son, Tischfield, Jay A.
Format: Artigo
Jezik:Inglês
Izdano: Mary Ann Liebert, Inc. 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128761/
https://ncbi.nlm.nih.gov/pubmed/20491544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2010.0159
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