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Efficient Gene Targeting by Homologous Recombination in Rat Embryonic Stem Cells

The rat is the preferred experimental animal in many biological studies. With the recent derivation of authentic rat embryonic stem (ES) cells it is now feasible to apply state-of-the art genetic engineering in this species using homologous recombination. To establish whether rat ES cells are amenab...

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Detalhes bibliográficos
Main Authors: Meek, Stephen, Buehr, Mia, Sutherland, Linda, Thomson, Alison, Mullins, John J., Smith, Andrew J., Burdon, Tom
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997056/
https://ncbi.nlm.nih.gov/pubmed/21151976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014225
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