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Lipid Modifications of Sonic Hedgehog Ligand Dictate Cellular Reception and Signal Response

BACKGROUND: Sonic hedgehog (Shh) signaling regulates cell growth during embryonic development, tissue homeostasis and tumorigenesis. Concentration-dependent cellular responses to secreted Shh protein are essential for tissue patterning. Shh ligand is covalently modified by two lipid moieties, choles...

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Detalhes bibliográficos
Main Authors: Grover, Vandana K., Valadez, J. Gerardo, Bowman, Aaron B., Cooper, Michael K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128587/
https://ncbi.nlm.nih.gov/pubmed/21747935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021353
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