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Expression of Hedgehog ligand and signal transduction components in mutually distinct isocitrate dehydrogenase mutant glioma cells supports a role for paracrine signaling

Hedgehog signaling regulates the growth of malignant gliomas by a ligand dependent mechanism. The cellular source of Hedgehog ligand and mode of signaling have not been clearly defined due to the lack of methods to definitively identify neoplastic cells in glioma specimens. Using an antibody specifi...

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Détails bibliographiques
Publié dans:J Neurooncol
Auteurs principaux: Abiria, Sunday A., Williams, Thomas V., Munden, Alexander L., Grover, Vandana K., Wallace, Ato, Lundberg, Christopher J., Valadez, J. Gerardo, Cooper, Michael K.
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4290668/
https://ncbi.nlm.nih.gov/pubmed/24867209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-014-1481-7
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