Expression of Hedgehog ligand and signal transduction components in mutually distinct isocitrate dehydrogenase mutant glioma cells supports a role for paracrine signaling

Hedgehog signaling regulates the growth of malignant gliomas by a ligand dependent mechanism. The cellular source of Hedgehog ligand and mode of signaling have not been clearly defined due to the lack of methods to definitively identify neoplastic cells in glioma specimens. Using an antibody specifi...

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Bibliographic Details
Published in:J Neurooncol
Main Authors: Abiria, Sunday A., Williams, Thomas V., Munden, Alexander L., Grover, Vandana K., Wallace, Ato, Lundberg, Christopher J., Valadez, J. Gerardo, Cooper, Michael K.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4290668/
https://ncbi.nlm.nih.gov/pubmed/24867209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-014-1481-7
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