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Two checkpoint complexes are independently recruited to sites of DNA damage in vivo

The Ddc1/Rad17/Mec3 complex and Rad24 are DNA damage checkpoint components with limited homology to replication factors PCNA and RF-C, respectively, suggesting that these factors promote checkpoint activation by “sensing” DNA damage directly. Mec1 kinase, however, phosphorylates the checkpoint prote...

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Bibliografiske detaljer
Main Authors: Melo, Justine A., Cohen, Jen, Toczyski, David P.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2001
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC312815/
https://ncbi.nlm.nih.gov/pubmed/11691833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.903501
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