Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells

Damage recognition by repair/checkpoint factors is the critical first step of the DNA damage response. DNA double strand breaks (DSBs) activate checkpoint signaling and are repaired by nonhomologous end-joining (NHEJ) and homologous recombination (HR) pathways. However, in vivo kinetics of the indiv...

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Bibliographic Details
Main Authors: Kim, Jong-Soo, Krasieva, Tatiana B., Kurumizaka, Hitoshi, Chen, David J., Taylor, A. Malcolm R., Yokomori, Kyoko
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2005
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171485/
https://ncbi.nlm.nih.gov/pubmed/16061690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200411083
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