Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator

Ikaros is a unique regulator of lymphopoiesis that associates with pericentromeric heterochromatin and has been implicated in heritable gene inactivation. Binding and competition experiments demonstrate that Ikaros dimers compete with an Ets activator for occupancy of the lymphocyte-specific TdT pro...

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Publicado en:Genes Dev
Autores principales: Trinh, Le A., Ferrini, Roger, Cobb, Bradley S., Weinmann, Amy S., Hahm, Kyungmin, Ernst, Patricia, Garraway, Isla P., Merkenschlager, Matthias, Smale, Stephen T.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2001
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312741/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11459831/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.905601
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