Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator

Ikaros is a unique regulator of lymphopoiesis that associates with pericentromeric heterochromatin and has been implicated in heritable gene inactivation. Binding and competition experiments demonstrate that Ikaros dimers compete with an Ets activator for occupancy of the lymphocyte-specific TdT pro...

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Detalhes bibliográficos

Publicado no:	Genes Dev
Principais autores:	Trinh, Le A., Ferrini, Roger, Cobb, Bradley S., Weinmann, Amy S., Hahm, Kyungmin, Ernst, Patricia, Garraway, Isla P., Merkenschlager, Matthias, Smale, Stephen T.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Cold Spring Harbor Laboratory Press 2001
Assuntos:	Research Paper
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312741/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11459831/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.905601
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