ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

The p53 tumor suppressor protein, a key regulator of cellular responses to genotoxic stress, is stabilized and activated after DNA damage. The rapid activation of p53 by ionizing radiation and radiomimetic agents is largely dependent on the ATM kinase. p53 is phosphorylated by ATM shortly after DNA...

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Main Authors: Maya, Ruth, Balass, Moshe, Kim, Seong-Tae, Shkedy, Dganit, Leal, Juan-Fernando Martinez, Shifman, Ohad, Moas, Miri, Buschmann, Thomas, Ronai, Ze'ev, Shiloh, Yosef, Kastan, Michael B., Katzir, Ephraim, Oren, Moshe
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2001
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Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC312683/
https://ncbi.nlm.nih.gov/pubmed/11331603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.886901
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