ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

The p53 tumor suppressor protein, a key regulator of cellular responses to genotoxic stress, is stabilized and activated after DNA damage. The rapid activation of p53 by ionizing radiation and radiomimetic agents is largely dependent on the ATM kinase. p53 is phosphorylated by ATM shortly after DNA...

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Detalhes bibliográficos
Publicado no:Genes Dev
Principais autores: Maya, Ruth, Balass, Moshe, Kim, Seong-Tae, Shkedy, Dganit, Leal, Juan-Fernando Martinez, Shifman, Ohad, Moas, Miri, Buschmann, Thomas, Ronai, Ze'ev, Shiloh, Yosef, Kastan, Michael B., Katzir, Ephraim, Oren, Moshe
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2001
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312683/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11331603/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.886901
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