ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

The p53 tumor suppressor protein, a key regulator of cellular responses to genotoxic stress, is stabilized and activated after DNA damage. The rapid activation of p53 by ionizing radiation and radiomimetic agents is largely dependent on the ATM kinase. p53 is phosphorylated by ATM shortly after DNA...

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Dettagli Bibliografici

Pubblicato in:	Genes Dev
Autori principali:	Maya, Ruth, Balass, Moshe, Kim, Seong-Tae, Shkedy, Dganit, Leal, Juan-Fernando Martinez, Shifman, Ohad, Moas, Miri, Buschmann, Thomas, Ronai, Ze'ev, Shiloh, Yosef, Kastan, Michael B., Katzir, Ephraim, Oren, Moshe
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Cold Spring Harbor Laboratory Press 2001
Soggetti:	Research Paper
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312683/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11331603/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.886901
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