ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

The p53 tumor suppressor protein, a key regulator of cellular responses to genotoxic stress, is stabilized and activated after DNA damage. The rapid activation of p53 by ionizing radiation and radiomimetic agents is largely dependent on the ATM kinase. p53 is phosphorylated by ATM shortly after DNA...

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Hlavní autoři: Maya, Ruth, Balass, Moshe, Kim, Seong-Tae, Shkedy, Dganit, Leal, Juan-Fernando Martinez, Shifman, Ohad, Moas, Miri, Buschmann, Thomas, Ronai, Ze'ev, Shiloh, Yosef, Kastan, Michael B., Katzir, Ephraim, Oren, Moshe
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2001
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC312683/
https://ncbi.nlm.nih.gov/pubmed/11331603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.886901
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