ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

The p53 tumor suppressor protein, a key regulator of cellular responses to genotoxic stress, is stabilized and activated after DNA damage. The rapid activation of p53 by ionizing radiation and radiomimetic agents is largely dependent on the ATM kinase. p53 is phosphorylated by ATM shortly after DNA...

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Bibliografski detalji
Glavni autori: Maya, Ruth, Balass, Moshe, Kim, Seong-Tae, Shkedy, Dganit, Leal, Juan-Fernando Martinez, Shifman, Ohad, Moas, Miri, Buschmann, Thomas, Ronai, Ze'ev, Shiloh, Yosef, Kastan, Michael B., Katzir, Ephraim, Oren, Moshe
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2001
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC312683/
https://ncbi.nlm.nih.gov/pubmed/11331603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.886901
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