Loss of Werner syndrome protein function promotes aberrant mitotic recombination

The chromosome 8p11–12 Werner syndrome (WRN ) locus encodes a RecQ helicase protein of unknown function that possesses both 3′ → 5′ helicase and 3′ → 5′ exonuclease activities. We show that WRN cell lines display a marked reduction in cell proliferation following mitotic recombination, and generate...

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Detalhes bibliográficos

Publicado no:	Genes Dev
Principais autores:	Prince, Polly R., Emond, Mary J., Monnat, Raymond J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Cold Spring Harbor Laboratory Press 2001
Assuntos:	Research Communication
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312674/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11316787/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.877001
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