Small Molecules Targeting Hepatitis C Virus-Encoded NS5A Cause Subcellular Redistribution of Their Target: Insights into Compound Modes of Action

The current standard of care for hepatitis C virus (HCV)-infected patients consists of lengthy treatment with interferon and ribavirin. To increase the effectiveness of HCV therapy, future regimens will incorporate multiple direct-acting antiviral (DAA) drugs. Recently, the HCV-encoded NS5A protein...

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Bibliographische Detailangaben
Hauptverfasser: Targett-Adams, Paul, Graham, Emily J. S., Middleton, Jenny, Palmer, Amy, Shaw, Stephen M., Lavender, Helen, Brain, Philip, Tran, Thien Duc, Jones, Lyn H., Wakenhut, Florian, Stammen, Blanda, Pryde, David, Pickford, Chris, Westby, Mike
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2011
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126509/
https://ncbi.nlm.nih.gov/pubmed/21507963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00215-11
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