Small Molecules Targeting Hepatitis C Virus-Encoded NS5A Cause Subcellular Redistribution of Their Target: Insights into Compound Modes of Action

The current standard of care for hepatitis C virus (HCV)-infected patients consists of lengthy treatment with interferon and ribavirin. To increase the effectiveness of HCV therapy, future regimens will incorporate multiple direct-acting antiviral (DAA) drugs. Recently, the HCV-encoded NS5A protein...

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Detalhes bibliográficos
Main Authors: Targett-Adams, Paul, Graham, Emily J. S., Middleton, Jenny, Palmer, Amy, Shaw, Stephen M., Lavender, Helen, Brain, Philip, Tran, Thien Duc, Jones, Lyn H., Wakenhut, Florian, Stammen, Blanda, Pryde, David, Pickford, Chris, Westby, Mike
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126509/
https://ncbi.nlm.nih.gov/pubmed/21507963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00215-11
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